Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 1.00 |
| ▸ | JAK2 | O60674 | 7/20 | 0.75 |
| ▸ | JAK1 | P23458 | 3/20 | 0.75 |
| ▸ | CDK9 | P50750 | 1/20 | 0.75 |
| ▸ | JAK3 | P52333 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1706323 | 1.00 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3512596 | 1.00 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3513207 | 1.00 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL1706159 | 1.00 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3514789 | 1.00 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3515236 | 0.90 | TYK2 (0.82) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3515022 | 0.90 | TYK2 (1.00) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3517299 | 0.90 | TYK2 (0.82) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3512735 | 0.90 | TYK2 (0.82) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL3514272 | 0.90 | TYK2 (0.82) | TYK2JAK2JAK1CDK9JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440529-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | F. Hoffmann-La Roche AG (CH) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010142752-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-16 | — | — | WO | disclosed |