Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.68 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.68 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.68 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.68 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.68 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.68 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.68 |
| ▸ | KDM1A | O60341 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18423189 | 0.95 | TRPV1 (0.75) | TRPV1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL18421284 | 0.89 | MAPT (0.77) | TRPV1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL28099312 | 0.87 | MAPT (0.74) | TRPV1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL18248619 | 0.85 | HDAC1 (0.65) | TRPV1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL7319492 | 0.85 | HDAC1 (0.77) | TRPV1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL7636110 | 0.84 | TRPV1 (0.77) | TRPV1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL8012743 | 0.84 | TRPV1 (0.81) | TRPV1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL7831891 | 0.84 | HDAC1 (0.67) | TRPV1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL22223521 | 0.83 | KDM1A (0.52) | TRPV1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL18256333 | 0.83 | HDAC1 (0.73) | TRPV1HDAC1HDAC2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11565994-B2 | Inhibitors of histone lysine specific demethylase (LSD1) and histone deacetylases (HDACS) | THE JOHNS HOPKINS UNIVERSITY (US) | 2023-01-31 | — | — | US | disclosed |
| US-20210009511-A1 | INHIBITORS OF HISTONE LYSINE SPECIFIC DEMETHYLASE (LSD1) AND HISTONE DEACETYLASES (HDACS) | THE JOHNS HOPKINS UNIVERSITY | 2021-01-14 | — | — | US | disclosed |
| CN-106458856-A | Inhibitors of histone lysine specific demethylase (lsd1) and histone deacetylases (hdacs) | 约翰霍普金斯大学 | 2017-02-22 | — | — | CN | disclosed |
| US-20170029366-A1 | INHIBITORS OF HISTONE LYSINE SPECIFIC DEMETHYLASE (LSD1) AND HISTONE DEACETYLASES (HDACS) | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-02-02 | — | — | US | disclosed |
| EP-3114109-A1 | INHIBITORS OF HISTONE LYSINE SPECIFIC DEMETHYLASE (LSD1) AND HISTONE DEACETYLASES (HDACS) | The Johns Hopkins University (US) | 2017-01-11 | — | — | EP | disclosed |
| WO-2015134973-A1 | INHIBITORS OF HISTONE LYSINE SPECIFIC DEMETHYLASE (LSD1) AND HISTONE DEACETYLASES (HDACS) | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11565994-B2 | Inhibitors of histone lysine specific demethylase (LSD1) and histone deacetylases (HDACS) | KDM1B, KDM2A, EHMT2 | TRPV1 3975/4885HDAC1 27/4885HDAC2 20/4885 |
| US-20210009511-A1 | INHIBITORS OF HISTONE LYSINE SPECIFIC DEMETHYLASE (LSD1) AND HISTONE DEACETYLASES (HDACS) | KDM1B, KDM2A, EHMT2 | TRPV1 3975/4885HDAC1 27/4885HDAC2 20/4885 |
| US-20170029366-A1 | INHIBITORS OF HISTONE LYSINE SPECIFIC DEMETHYLASE (LSD1) AND HISTONE DEACETYLASES (HDACS) | KDM1B, KDM2A, EHMT2 | TRPV1 3975/4885HDAC1 27/4885HDAC2 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.