Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Teneligliptin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 20/20 | 0.98 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.98 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.98 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.98 |
| ▸ | HRH1 | P35367 | 1/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Teneligliptin SCHEMBL2711577 | 1.00 | DPP4 (0.98) | DPP4DPP8DPP9PTGS2HRH1 | |
| Teneligliptin SCHEMBL17065851 | 1.00 | DPP4 (0.98) | DPP4DPP8DPP9PTGS2HRH1 | |
| Teneligliptin SCHEMBL17270087 | 0.99 | DPP4 (1.00) | DPP4DPP8DPP9PTGS2HRH1 | |
| Teneligliptin SCHEMBL161778 | 0.99 | DPP4 (1.00) | DPP4DPP8DPP9PTGS2HRH1 | |
| Teneligliptin SCHEMBL17270067 | 0.99 | DPP4 (1.00) | DPP4DPP8DPP9PTGS2HRH1 | |
| Teneligliptin SCHEMBL254082 | 0.99 | DPP4 (1.00) | DPP4DPP8DPP9PTGS2HRH1 | |
| Teneligliptin SCHEMBL16451097 | 0.99 | DPP4 (1.00) | DPP4DPP8DPP9PTGS2HRH1 | |
| Teneligliptin SCHEMBL14634647 | 0.98 | DPP4 (0.98) | DPP4DPP8DPP9PTGS2HRH1 | |
| Teneligliptin SCHEMBL2142591 | 0.98 | DPP4 (0.98) | DPP4DPP8DPP9PTGS2HRH1 | |
| Teneligliptin SCHEMBL17065854 | 0.97 | DPP4 (1.00) | DPP4DPP8DPP9PTGS2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015132679-A1 | TENELIGLIPTIN COMPOSITIONS | GLENMARK PHARMACEUTICALS LTD (IN) | 2015-09-11 | — | — | WO | disclosed |