Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.53 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.50 |
| ▸ | ABL1 | P00519 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1259693 | 0.82 | LRRK2 (0.56) | LRRK2MAP4K1ABL1HPGDKDR | |
| SCHEMBL3145952 | 0.82 | PIK3CA (0.50) | HPGDKDR | |
| SCHEMBL24305376 | 0.81 | LRRK2 (0.55) | LRRK2MAP4K1ABL1HPGDKDR | |
| SCHEMBL17065938 | 0.81 | MAP3K5 (0.56) | LRRK2MAP4K1ABL1HPGDKDR | |
| SCHEMBL1258121 | 0.74 | KDR (0.55) | LRRK2MAP4K1ABL1KDRAURKA | |
| SCHEMBL17066024 | 0.73 | LRRK2 (0.46) | LRRK2MAP4K1ABL1KDRAURKA | |
| SCHEMBL24296473 | 0.73 | LRRK2 (0.56) | LRRK2MAP4K1ABL1HPGDKDR | |
| SCHEMBL22380353 | 0.73 | LRRK2 (0.55) | LRRK2MAP4K1ABL1 | |
| SCHEMBL22380367 | 0.73 | LRRK2 (0.77) | LRRK2MAP4K1ABL1 | |
| SCHEMBL31557493 | 0.72 | JAK1 (0.57) | LRRK2HPGDKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015134171-A1 | HETEROARYLAMIDE INHIBITORS OF TBK1 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-09-11 | — | — | WO | disclosed |