Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17066336 | 0.96 | CYP3A4 (0.44) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL17066300 | 0.96 | CYP3A4 (0.45) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL889343 | 0.93 | CYP3A4 (0.42) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL17066339 | 0.92 | CYP3A4 (0.43) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL17066337 | 0.89 | CYP3A4 (0.39) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL15992705 | 0.89 | CYP3A4 (0.55) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL16062558 | 0.87 | CYP3A4 (0.43) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL17066319 | 0.87 | CYP3A4 (0.55) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL17066327 | 0.87 | CYP3A4 (0.42) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL12436388 | 0.87 | CYP3A4 (0.37) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9125904-B1 | Biphenyl imidazoles and related compounds useful for treating HCV infections | ACHILLION PHARMACEUTICALS, INC. (US) | 2015-09-08 | — | — | US | disclosed |
| US-9125904-B1 | Biphenyl imidazoles and related compounds useful for treating HCV infections | ACHILLION PHARMACEUTICALS, INC. (US) | 2015-09-08 | — | — | US | disclosed |