Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.78 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.64 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.58 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1706941 | 0.89 | EGFR (0.78) | EGFRALKNUAK1NUAK2 | |
| SCHEMBL27871462 | 0.89 | EGFR (0.61) | EGFRALK | |
| SCHEMBL1706808 | 0.88 | EGFR (1.00) | EGFRALKNUAK1NUAK2 | |
| SCHEMBL10128584 | 0.87 | EGFR (0.87) | EGFRALKNUAK1NUAK2 | |
| SCHEMBL29534133 | 0.86 | EGFR (0.90) | EGFRALKNUAK1NUAK2 | |
| SCHEMBL17201956 | 0.86 | ALK (0.68) | EGFRALK | |
| SCHEMBL1706237 | 0.85 | EGFR (1.00) | EGFRALKNUAK1NUAK2 | |
| SCHEMBL2120917 | 0.84 | EGFR (0.93) | EGFRALKNUAK1NUAK2 | |
| SCHEMBL9893628 | 0.82 | EGFR (1.00) | EGFRALKNUAK1NUAK2 | |
| SCHEMBL1706933 | 0.82 | EGFR (0.94) | EGFRALKNUAK1NUAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190040065-A1 | EGFR Inhibitors and Methods of Treating Disorders | DANA-FARBER CANCER INSTITUTE, INC. | 2019-02-07 | — | — | US | disclosed |
| US-9908884-B2 | EGFR inhibitors and methods of treating disorders | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-03-06 | — | — | US | disclosed |
| EP-2440559-B1 | EGFR INHIBITORS AND METHODS OF TREATING DISORDERS | DANA FARBER CANCER INST INC (US) | 2018-01-10 | — | — | EP | disclosed |
| US-20120094999-A1 | EGFR INHIBITORS AND METHODS OF TREATING DISORDERS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2012-04-19 | — | — | US | disclosed |
| US-20120094999-A1 | EGFR INHIBITORS AND METHODS OF TREATING DISORDERS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2012-04-19 | — | — | US | disclosed |
| EP-2440559-A2 | EGFR INHIBITORS AND METHODS OF TREATING DISORDERS | Dana-Farber Cancer Institute, Inc. (US) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010129053-A2 | EGFR INHIBITORS AND METHODS OF TREATING DISORDERS | DANA FARBER CANCER INSTITUTE (US) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094999-A1 | EGFR INHIBITORS AND METHODS OF TREATING DISORDERS | EGFR, ERBB2, ERBB4 | EGFR 1/4885ALK 32/4885NUAK1 2357/4885 |
| US-20190040065-A1 | EGFR Inhibitors and Methods of Treating Disorders | EGFR, ERBB2, ERBB4 | EGFR 1/4885ALK 32/4885NUAK1 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.