Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.65 |
| ▸ | PRKDC | P78527 | 1/20 | 0.65 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12475475 | 1.00 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL12475904 | 1.00 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL12475480 | 1.00 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL1030753 | 0.90 | AKT1 (1.00) | AKT1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL17072336 | 0.83 | AKT1 (0.83) | AKT1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL12475906 | 0.83 | AKT1 (0.83) | AKT1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL12475863 | 0.83 | AKT1 (0.83) | AKT1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL12475868 | 0.83 | AKT1 (0.83) | AKT1PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL12475838 | 0.79 | AKT1 (1.00) | AKT1 | |
| SCHEMBL12475837 | 0.79 | AKT1 (1.00) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133168-B2 | Pyrimidine derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors | SANOFI (FR) | 2015-09-15 | — | — | US | claimed |