Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17064891 | 0.85 | KLKB1 (0.50) | KLKB1 | |
| SCHEMBL17073530 | 0.85 | KLKB1 (0.50) | KLKB1 | |
| SCHEMBL18623226 | 0.80 | KLKB1 (0.53) | KLKB1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL29580643 | 0.80 | KLKB1 (0.53) | KLKB1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL29825742 | 0.80 | KLKB1 (0.53) | KLKB1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL17064666 | 0.80 | KLKB1 (0.53) | KLKB1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL25891617 | 0.74 | KLKB1 (0.49) | KLKB1 | |
| SCHEMBL23428909 | 0.74 | KLKB1 (0.49) | KLKB1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL29581037 | 0.72 | KLKB1 (0.46) | KLKB1 | |
| SCHEMBL17064336 | 0.72 | KLKB1 (0.46) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015134998-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2015-09-11 | — | — | WO | disclosed |