Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707990 | 1.00 | CHEK1 (0.31) | CHEK1ATRPDCD1ATRIPCD274 | |
| SCHEMBL1707946 | 1.00 | CHEK1 (0.31) | CHEK1ATRPDCD1ATRIPCD274 | |
| SCHEMBL1708123 | 0.93 | — | — | |
| SCHEMBL1708087 | 0.93 | — | — | |
| SCHEMBL1707936 | 0.93 | TSHR (0.32) | — | |
| SCHEMBL1708050 | 0.93 | TSHR (0.32) | — | |
| SCHEMBL1708118 | 0.93 | TSHR (0.32) | — | |
| SCHEMBL1708329 | 0.92 | — | — | |
| SCHEMBL1708042 | 0.91 | — | — | |
| SCHEMBL1708327 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |