Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 11/20 | 0.70 |
| ▸ | MAPT | P10636 | 10/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.70 |
| ▸ | HTT | P42858 | 6/20 | 0.70 |
| ▸ | MEN1 | O00255 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | TP53 | P04637 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.70 |
| ▸ | ATM | Q13315 | 2/20 | 0.68 |
| ▸ | LIG1 | P18858 | 2/20 | 0.61 |
| ▸ | LIG3 | P49916 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | CCR6 | P51684 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18114768 | 0.80 | MAPT (0.70) | KDM4EL3MBTL1MAPTTDP1KMT2A | |
| SCHEMBL18114764 | 0.80 | MAPT (0.70) | KDM4EL3MBTL1MAPTTDP1KMT2A | |
| SCHEMBL13401789 | 0.76 | LIG1 (1.00) | KDM4EL3MBTL1MAPTTDP1KMT2A | |
| SCHEMBL13401821 | 0.76 | LIG1 (0.75) | KDM4EL3MBTL1MAPTTDP1KMT2A | |
| SCHEMBL19298155 | 0.76 | LIG1 (1.00) | KDM4EL3MBTL1MAPTTDP1KMT2A | |
| SCHEMBL15457450 | 0.75 | MEN1 (0.77) | KDM4EL3MBTL1MAPTTDP1KMT2A | |
| SCHEMBL683798 | 0.74 | KDM4E (0.78) | KDM4EL3MBTL1MAPTTDP1KMT2A | |
| SCHEMBL31530751 | 0.73 | KDM4E (0.69) | KDM4EL3MBTL1MAPTTDP1KMT2A | |
| SCHEMBL1638695 | 0.73 | MEN1 (0.78) | KDM4EL3MBTL1MAPTTDP1KMT2A | |
| SCHEMBL21292847 | 0.73 | DUSP3 (0.82) | KDM4EL3MBTL1MAPTTDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9623008-B2 | Targeting abnormal DNA repair in therapy-resistant breast and pancreatic cancers | STC.UNM (US) | 2017-04-18 | — | — | US | disclosed |
| US-9132120-B1 | Targeting abnormal DNA repair in therapy-resistant breast and pancreatic cancers | STC.UNM (US) | 2015-09-15 | — | — | US | disclosed |