Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549155 | 1.00 | FFAR4 (0.42) | FFAR4ADAM10MMP2MMP9GRM5 | |
| SCHEMBL549154 | 1.00 | FFAR4 (0.42) | FFAR4ADAM10MMP2MMP9GRM5 | |
| SCHEMBL549478 | 0.90 | KMT2A (0.49) | FFAR4KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL17082084 | 0.90 | KMT2A (0.49) | FFAR4KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL549479 | 0.90 | KMT2A (0.49) | FFAR4KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL550557 | 0.90 | AKR1C3 (0.47) | MMP2CA12CA1CA9LMNA | |
| SCHEMBL550556 | 0.90 | AKR1C3 (0.47) | MMP2CA12CA1CA9LMNA | |
| SCHEMBL17082051 | 0.90 | AKR1C3 (0.47) | MMP2CA12CA1CA9LMNA | |
| SCHEMBL550354 | 0.88 | AKR1C3 (0.46) | ADAM10MMP2LMNAALDH1A1HPGD | |
| SCHEMBL550355 | 0.88 | AKR1C3 (0.46) | ADAM10MMP2LMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |