Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570140 | 1.00 | TAAR1 (0.37) | TAAR1S1PR1TP53MAPTTHRB | |
| SCHEMBL17081999 | 0.92 | S1PR1 (0.41) | TAAR1S1PR1TP53MAPTTHRB | |
| SCHEMBL4570137 | 0.92 | S1PR1 (0.41) | TAAR1S1PR1TP53MAPTTHRB | |
| SCHEMBL17082089 | 0.90 | ALK (0.36) | TAAR1S1PR1TP53MAPTTHRB | |
| SCHEMBL4570139 | 0.90 | ALK (0.36) | TAAR1S1PR1TP53MAPTTHRB | |
| SCHEMBL551713 | 0.90 | KDM4E (0.42) | S1PR1MAPTSMN1; SMN2ALKCYP2C9 | |
| SCHEMBL4570036 | 0.90 | KDM4E (0.38) | MAPTCYP2C9KDM4E | |
| SCHEMBL550052 | 0.90 | KDM4E (0.42) | S1PR1MAPTSMN1; SMN2ALKCYP2C9 | |
| SCHEMBL2702598 | 0.90 | KDM4E (0.42) | S1PR1MAPTSMN1; SMN2ALKCYP2C9 | |
| SCHEMBL550053 | 0.90 | KDM4E (0.42) | S1PR1MAPTSMN1; SMN2ALKCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |