SCHEMBL17082145 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	AKR1C3	P42330	6/20	0.52

▸	ALDH1A1	P00352	3/20	0.52

▸	SMN1; SMN2	Q16637	2/20	0.52

▸	LMNA	P02545	2/20	0.52

▸	HPGD	P15428	1/20	0.52

▸	HTT	P42858	1/20	0.52

▸	HSD11B1	P28845	4/20	0.46

▸	GFER	P55789	3/20	0.46

▸	MEN1	O00255	1/20	0.41

▸	KMT2A	Q03164	1/20	0.41

▸	MAPT	P10636	2/20	0.38

▸	ADAMTS5	Q9UNA0	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL549158	1.00	AKR1C3 (0.52)	AKR1C3ALDH1A1SMN1; SMN2LMNAHPGD
SCHEMBL549159	1.00	AKR1C3 (0.52)	AKR1C3ALDH1A1SMN1; SMN2LMNAHPGD
SCHEMBL550355	0.90	AKR1C3 (0.46)	AKR1C3ALDH1A1SMN1; SMN2LMNAHPGD
SCHEMBL550354	0.90	AKR1C3 (0.46)	AKR1C3ALDH1A1SMN1; SMN2LMNAHPGD
SCHEMBL550557	0.89	AKR1C3 (0.47)	AKR1C3ALDH1A1LMNAHTTHSD11B1
SCHEMBL551118	0.89	MAPT (0.46)	AKR1C3ALDH1A1SMN1; SMN2LMNAHPGD
SCHEMBL17082051	0.89	AKR1C3 (0.47)	AKR1C3ALDH1A1LMNAHTTHSD11B1
SCHEMBL550556	0.89	AKR1C3 (0.47)	AKR1C3ALDH1A1LMNAHTTHSD11B1
SCHEMBL551119	0.89	MAPT (0.46)	AKR1C3ALDH1A1SMN1; SMN2LMNAHPGD
SCHEMBL17082076	0.89	MAPT (0.46)	AKR1C3ALDH1A1SMN1; SMN2LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1812005-B1	LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS	INCYTE CORP (US)	2015-09-16	—	—	EP	disclosed