Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550605 | 1.00 | SCN9A (0.40) | SCN9AHSD11B1PTPN11DRD2DRD3 | |
| SCHEMBL550716 | 1.00 | SCN9A (0.40) | SCN9AHSD11B1PTPN11DRD2DRD3 | |
| SCHEMBL17082153 | 1.00 | SCN9A (0.40) | SCN9AHSD11B1PTPN11DRD2DRD3 | |
| SCHEMBL2697981 | 1.00 | SCN9A (0.40) | SCN9AHSD11B1PTPN11DRD2DRD3 | |
| SCHEMBL4570124 | 1.00 | SCN9A (0.40) | SCN9AHSD11B1PTPN11DRD2DRD3 | |
| SCHEMBL4570123 | 1.00 | SCN9A (0.40) | SCN9AHSD11B1PTPN11DRD2DRD3 | |
| SCHEMBL2699529 | 0.91 | SCN9A (0.43) | SCN9AHSD11B1DRD2NOTUM | |
| SCHEMBL549671 | 0.91 | SCN9A (0.43) | SCN9AHSD11B1DRD2NOTUM | |
| SCHEMBL549672 | 0.91 | SCN9A (0.43) | SCN9AHSD11B1DRD2NOTUM | |
| SCHEMBL550118 | 0.91 | SCN9A (0.43) | SCN9AHSD11B1DRD2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-B1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2015-09-16 | — | — | EP | disclosed |