Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | CCR8 | P51685 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2707203 | 1.00 | UHRF1 (0.43) | UHRF1DYRK1AMEN1NPC1MAPT | |
| SCHEMBL2958768 | 1.00 | UHRF1 (0.43) | UHRF1DYRK1AMEN1NPC1MAPT | |
| SCHEMBL5256862 | 0.79 | KDM1A (0.47) | MEN1NPC1MAPTALOX15CASP1 | |
| SCHEMBL5256859 | 0.79 | KDM1A (0.47) | MEN1NPC1MAPTALOX15CASP1 | |
| SCHEMBL9798174 | 0.78 | UHRF1 (0.48) | UHRF1DYRK1AMEN1MAPTKMT2A | |
| SCHEMBL14153950 | 0.78 | UHRF1 (0.48) | UHRF1DYRK1AMEN1MAPTKMT2A | |
| SCHEMBL9798181 | 0.78 | UHRF1 (0.48) | UHRF1DYRK1AMEN1MAPTKMT2A | |
| SCHEMBL6630611 | 0.77 | — | — | |
| SCHEMBL27790862 | 0.77 | MAPT (0.62) | MEN1NPC1MAPTALOX15CASP1 | |
| SCHEMBL27898404 | 0.77 | MAPT (0.62) | MEN1NPC1MAPTALOX15CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015138689-A1 | FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF | FORUM PHARMACEUTICALS INC. (US) | 2015-09-17 | — | — | WO | disclosed |