Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 8/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | SPR | P35270 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6930694 | 0.96 | HDAC6 (0.54) | HDAC6HPGDLMNACYP1A2CYP2C9 | |
| SCHEMBL18711813 | 0.82 | HPGD (0.54) | HPGDLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14638381 | 0.82 | PARP1 (0.54) | HPGDLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14637875 | 0.79 | PARP1 (0.50) | HPGDLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12050029 | 0.79 | POLB (0.52) | HPGDLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14638235 | 0.77 | HPGD (0.51) | HPGDLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7776883 | 0.77 | PARP1 (0.60) | HDAC6LMNAKDM4EPARP1HTR2C | |
| SCHEMBL14603558 | 0.77 | TNKS2 (0.54) | PARP1 | |
| SCHEMBL9843755 | 0.77 | HPGD (0.59) | HPGDLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL31128493 | 0.76 | HPGD (0.51) | HPGDCYP1A2CYP2C9CYP2C19MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105793264-B | Substituted Dihydrobenzofuranes piperidines ketone derivatives, its preparation and purposes | 四川海思科制药有限公司 | 2017-09-01 | — | — | CN | disclosed |
| CN-105793264-A | Substituted dihydrobenzofuran-piperidine-ketone derivative, preparation and use thereof | 四川海思科制药有限公司 | 2016-07-20 | — | — | CN | disclosed |
| WO-2015135461-A1 | SUBSTITUTED DIHYDROBENZOFURAN-PIPERIDINE-KETONE DERIVATIVE, PREPARATION AND USE THEREOF | 四川海思科制药有限公司 | 2015-09-17 | — | — | WO | disclosed |