Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 9/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 6/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 6/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 6/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | CASP1 | P29466 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | CASP7 | P55210 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.79 |
| ▸ | MAPT | P10636 | 3/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.79 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 3/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Akuammigine SCHEMBL15384550 | 1.00 | CYP2D6 (1.00) | CYP2D6MEN1KMT2AADRA2AADRA2B | |
| Akuammigine SCHEMBL15384548 | 1.00 | CYP2D6 (1.00) | CYP2D6MEN1KMT2AADRA2AADRA2B | |
| Akuammigine SCHEMBL309915 | 1.00 | CYP2D6 (1.00) | CYP2D6MEN1KMT2AADRA2AADRA2B | |
| Akuammigine SCHEMBL15384543 | 1.00 | CYP2D6 (1.00) | CYP2D6MEN1KMT2AADRA2AADRA2B | |
| Akuammigine SCHEMBL15384556 | 1.00 | CYP2D6 (1.00) | CYP2D6MEN1KMT2AADRA2AADRA2B | |
| Akuammigine SCHEMBL17088324 | 1.00 | CYP2D6 (1.00) | CYP2D6MEN1KMT2AADRA2AADRA2B | |
| Tetrahydroalstonine SCHEMBL564502 | 1.00 | CYP2D6 (1.00) | CYP2D6MEN1KMT2AADRA2AADRA2B | |
| Akuammigine SCHEMBL17088322 | 1.00 | CYP2D6 (1.00) | CYP2D6MEN1KMT2AADRA2AADRA2B | |
| Akuammigine SCHEMBL15384557 | 1.00 | CYP2D6 (1.00) | CYP2D6MEN1KMT2AADRA2AADRA2B | |
| Akuammigine SCHEMBL15384547 | 1.00 | CYP2D6 (1.00) | CYP2D6MEN1KMT2AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9138433-B2 | Indole alkaloid compounds as melanogenesis promoters and uses thereof | NEW YORK UNIVERSITY (US) | 2015-09-22 | — | — | US | disclosed |
| US-9138433-B2 | Indole alkaloid compounds as melanogenesis promoters and uses thereof | NEW YORK UNIVERSITY (US) | 2015-09-22 | — | — | US | disclosed |