Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 15/20 | 0.66 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.59 |
| ▸ | FLT3 | P36888 | 4/20 | 0.57 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.57 |
| ▸ | MERTK | Q12866 | 4/20 | 0.57 |
| ▸ | GAS6 | Q14393 | 4/20 | 0.57 |
| ▸ | AXL | P30530 | 2/20 | 0.57 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14657596 | 0.89 | MAPK8 (0.83) | MAPK8MAPK9SYK | |
| SCHEMBL14657597 | 0.89 | MAPK8 (0.83) | MAPK8MAPK9SYK | |
| SCHEMBL14657833 | 0.89 | MAPK8 (0.83) | MAPK8MAPK9SYK | |
| SCHEMBL14667173 | 0.89 | MAPK8 (0.83) | MAPK8MAPK9SYK | |
| SCHEMBL14657828 | 0.89 | MAPK8 (0.83) | MAPK8MAPK9SYK | |
| SCHEMBL14658179 | 0.87 | MAPK8 (0.84) | MAPK8MAPK9SYK | |
| SCHEMBL14658180 | 0.87 | MAPK8 (0.84) | MAPK8MAPK9SYK | |
| SCHEMBL17088459 | 0.87 | MAPK8 (0.84) | MAPK8MAPK9SYK | |
| SCHEMBL14656999 | 0.87 | MAPK8 (0.84) | MAPK8MAPK9SYK | |
| SCHEMBL14657000 | 0.87 | MAPK8 (0.84) | MAPK8MAPK9SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139534-B2 | Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2015-09-22 | — | — | US | disclosed |