Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.60 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.60 |
| ▸ | SYK | P43405 | 14/20 | 0.60 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | STAT6 | P42226 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14658552 | 0.85 | MAPK8 (0.61) | MAPK8MAPK9SYKZAP70EGFR | |
| SCHEMBL14657619 | 0.83 | IGF1R (0.64) | MAPK8MAPK9SYKZAP70EGFR | |
| SCHEMBL28110005 | 0.83 | MAPK8 (0.71) | MAPK8MAPK9SYKZAP70EGFR | |
| SCHEMBL29761550 | 0.82 | SYK (0.72) | MAPK8MAPK9SYKZAP70EGFR | |
| SCHEMBL14659023 | 0.82 | SYK (0.72) | MAPK8MAPK9SYKZAP70EGFR | |
| SCHEMBL14658078 | 0.81 | SYK (0.67) | MAPK8MAPK9SYKZAP70EGFR | |
| SCHEMBL14658869 | 0.78 | MAPK8 (0.72) | MAPK8MAPK9SYKZAP70EGFR | |
| SCHEMBL1313173 | 0.78 | MAPK8 (0.58) | MAPK8MAPK9SYKZAP70EGFR | |
| SCHEMBL17088514 | 0.78 | MAPK9 (0.78) | MAPK8MAPK9SYKZAP70EGFR | |
| SCHEMBL14656538 | 0.78 | EGFR (0.69) | MAPK8MAPK9SYKZAP70EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139534-B2 | Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2015-09-22 | — | — | US | disclosed |