Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | CLK3 | P49761 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565822 | 1.00 | BTK (0.39) | BTKKCNH2SMOPGRGPR183 | |
| SCHEMBL13565556 | 0.89 | SYK (0.40) | BTKKCNH2METKMT2AKDM1A | |
| SCHEMBL11935391 | 0.87 | BTK (0.37) | BTKKCNH2SMOPGRGPR183 | |
| SCHEMBL13439104 | 0.87 | BTK (0.37) | BTKKCNH2SMOPGRGPR183 | |
| SCHEMBL17090150 | 0.87 | BTK (0.37) | BTKKCNH2SMOPGRGPR183 | |
| SCHEMBL13564738 | 0.85 | MAPT (0.43) | LRRK2 | |
| SCHEMBL11936149 | 0.85 | MAPT (0.43) | LRRK2 | |
| SCHEMBL13565140 | 0.85 | MAPT (0.43) | LRRK2 | |
| SCHEMBL17089987 | 0.85 | MAPT (0.43) | LRRK2 | |
| SCHEMBL10133762 | 0.82 | NPY5R (0.52) | BTKKCNH2SMOPGRGPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |