Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.38 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565311 | 1.00 | GRIA1 (0.44) | GRIA1POLBHTR1ANPY5RPGAM1 | |
| SCHEMBL17090209 | 1.00 | GRIA1 (0.44) | GRIA1POLBHTR1ANPY5RPGAM1 | |
| SCHEMBL13565229 | 1.00 | GRIA1 (0.44) | GRIA1POLBHTR1ANPY5RPGAM1 | |
| SCHEMBL11935053 | 0.87 | MAPT (0.44) | GRIA1HTR1ANPY5RMAPT | |
| SCHEMBL11941099 | 0.87 | MAPT (0.44) | GRIA1HTR1ANPY5RMAPT | |
| SCHEMBL17090211 | 0.87 | MAPT (0.44) | GRIA1HTR1ANPY5RMAPT | |
| SCHEMBL13564965 | 0.84 | POLB (0.48) | GRIA1POLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL11941131 | 0.84 | GRIA1 (0.50) | GRIA1HTR1ANPY5RMAPTALDH1A1 | |
| SCHEMBL13565191 | 0.84 | POLB (0.39) | POLBPGAM1CNR2MAPTALDH1A1 | |
| SCHEMBL17090265 | 0.84 | POLB (0.39) | POLBPGAM1CNR2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |