Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 1/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 16/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565973 | 1.00 | GRIA4 (0.46) | GRIA4GRIA2NPC1RAB9ANPY5R | |
| SCHEMBL17090527 | 0.90 | EPHX1 (0.42) | GRIA4GRIA2NPY5RCRHR1 | |
| SCHEMBL13565851 | 0.90 | EPHX1 (0.42) | GRIA4GRIA2NPY5RCRHR1 | |
| SCHEMBL13565147 | 0.88 | GRIA4 (0.45) | GRIA4GRIA2NPY5RCYP3A4 | |
| SCHEMBL17090377 | 0.88 | GRIA4 (0.45) | GRIA4GRIA2NPY5RCYP3A4 | |
| SCHEMBL17090049 | 0.87 | GRIA2 (0.42) | GRIA4GRIA2NPY5R | |
| SCHEMBL13564970 | 0.87 | GRIA2 (0.46) | GRIA4GRIA2NPC1RAB9ANPY5R | |
| SCHEMBL13565560 | 0.87 | GRIA4 (0.46) | GRIA4GRIA2NPY5R | |
| SCHEMBL11935400 | 0.87 | GRIA4 (0.37) | GRIA4GRIA2NPY5R | |
| SCHEMBL11935089 | 0.87 | GRIA2 (0.42) | GRIA4GRIA2NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |