Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 7/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13566013 | 1.00 | MAPT (0.43) | MAPTBRD4HDAC6ALDH1A1GAA | |
| SCHEMBL10134420 | 0.88 | MAPT (0.50) | MAPTALDH1A1GAATP53ALOX15 | |
| SCHEMBL10114811 | 0.88 | MAPT (0.50) | MAPTALDH1A1GAATP53ALOX15 | |
| SCHEMBL13566028 | 0.86 | BRD4 (0.44) | BRD4HDAC6GAA | |
| SCHEMBL11935766 | 0.86 | BRD4 (0.44) | BRD4HDAC6GAA | |
| SCHEMBL11935268 | 0.86 | MAPT (0.43) | MAPTBRD4HDAC6ALDH1A1GAA | |
| SCHEMBL13565457 | 0.86 | MAPT (0.43) | MAPTBRD4HDAC6ALDH1A1GAA | |
| SCHEMBL11941099 | 0.84 | MAPT (0.44) | MAPTBRD4LRRK2 | |
| SCHEMBL11935053 | 0.84 | MAPT (0.44) | MAPTBRD4LRRK2 | |
| SCHEMBL17090211 | 0.84 | MAPT (0.44) | MAPTBRD4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |