Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.55 |
| ▸ | LCK | P06239 | 3/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.45 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.44 |
| ▸ | PRKDC | P78527 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | SRC | P12931 | 4/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | HCK | P08631 | 3/20 | 0.43 |
| ▸ | MTOR | P42345 | 3/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.43 |
| ▸ | TEK | Q02763 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090621 | 0.88 | BTK (0.71) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL17265759 | 0.84 | BTK (0.52) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL14617751 | 0.80 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL14617721 | 0.78 | BTK (0.57) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL17265753 | 0.72 | BTK (0.52) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL17090632 | 0.72 | BTK (0.68) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL17264223 | 0.72 | RET (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL30586962 | 0.71 | BTK (1.00) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL6431516 | 0.71 | BTK (1.00) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL17090581 | 0.71 | BTK (0.63) | BTKLCKLYNNUDT14NUDT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9138436-B2 | Inhibitors of Bruton's tyrosine kinase | PHARMACYCLICS LLC (US) | 2015-09-22 | — | — | US | disclosed |