Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 19/20 | 0.35 |
| ▸ | PDCD1LG2 | Q9BQ51 | 14/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2414941 | 1.00 | CD274 (0.35) | CD274PDCD1LG2PDCD1DDB1CRBN | |
| SCHEMBL2414945 | 1.00 | CD274 (0.35) | CD274PDCD1LG2PDCD1DDB1CRBN | |
| SCHEMBL2414041 | 0.84 | CD274 (0.37) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL2414038 | 0.84 | CD274 (0.37) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL2415154 | 0.76 | CD274 (0.35) | CD274PDCD1LG2PDCD1DDB1CRBN | |
| SCHEMBL2415155 | 0.76 | CD274 (0.35) | CD274PDCD1LG2PDCD1DDB1CRBN | |
| SCHEMBL12324622 | 0.74 | DDB1 (0.40) | CD274PDCD1LG2PDCD1DDB1CRBN | |
| SCHEMBL2415158 | 0.73 | CCR1 (0.37) | CD274PDCD1LG2 | |
| SCHEMBL2414661 | 0.72 | IRAK4 (0.33) | CD274PDCD1LG2PDCD1DDB1CRBN | |
| SCHEMBL2412187 | 0.72 | CD274 (0.33) | CD274PDCD1LG2PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2921489-B1 | 2-PYRIDONE COMPOUND | NISSAN CHEMICAL IND LTD (JP) | 2017-09-06 | — | — | EP | disclosed |
| EP-2921489-A1 | 2-PYRIDONE COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2015-09-23 | — | — | EP | disclosed |