Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 12/20 | 0.52 |
| ▸ | STIM1 | Q13586 | 3/20 | 0.47 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.47 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.47 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15395924 | 0.86 | STIM1 (0.58) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL15395848 | 0.85 | IL2 (0.54) | IL2STIM1ORAI1ORAI2TRPA1 | |
| SCHEMBL15395969 | 0.84 | STIM1 (0.58) | IL2STIM1ORAI1ORAI2TRPA1 | |
| SCHEMBL5550536 | 0.81 | IL2 (0.62) | IL2STIM1ORAI1ORAI2ORAI3 | |
| SCHEMBL12155960 | 0.79 | IL2 (0.48) | IL2STIM1ORAI1ORAI2ORAI3 | |
| SCHEMBL15395847 | 0.79 | IL2 (0.59) | IL2STIM1ORAI1ORAI2TRPA1 | |
| SCHEMBL15395973 | 0.78 | IL2 (0.61) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL15395983 | 0.78 | IL2 (0.49) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL13321942 | 0.78 | NTRK1 (0.44) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL2305855 | 0.78 | NPC1 (0.43) | IL2STIM1ORAI1ORAI2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493427-B2 | Compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2016-11-15 | — | — | US | disclosed |
| US-20150266829-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | PRCL Research Inc. (CA) | 2015-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266829-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | CCR1, CCR9, CXCR2 | IL2 21/4885STIM1 2094/4885ORAI1 1129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.