Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 4/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 2/20 | 0.34 |
| ▸ | ACE | P12821 | 4/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17062296 | 1.00 | XIAP (0.39) | XIAPELANEBUB1ACEMME | |
| SCHEMBL16466124 | 1.00 | XIAP (0.39) | XIAPELANEBUB1ACEMME | |
| SCHEMBL16466125 | 1.00 | XIAP (0.39) | XIAPELANEBUB1ACEMME | |
| SCHEMBL17062773 | 0.87 | XIAP (0.36) | XIAPELANEBUB1FNTAFNTB | |
| SCHEMBL17062550 | 0.87 | XIAP (0.35) | XIAPELANEBUB1FNTAFNTB | |
| SCHEMBL17062875 | 0.87 | XIAP (0.35) | XIAPELANEBUB1FNTAFNTB | |
| SCHEMBL17062877 | 0.87 | XIAP (0.35) | XIAPELANEBUB1FNTAFNTB | |
| SCHEMBL16462284 | 0.87 | XIAP (0.35) | XIAPELANEBUB1FNTAFNTB | |
| SCHEMBL17044930 | 0.86 | XIAP (0.54) | XIAPACE | |
| SCHEMBL16466352 | 0.86 | XIAP (0.54) | XIAPACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906559-B1 | AZAINDOLINES | HOFFMANN LA ROCHE (CH) | 2017-02-08 | — | — | EP | disclosed |
| US-9309248-B2 | Azaindolines | HOFFMANN-LA ROCHE INC. (US) | 2016-04-12 | — | — | US | disclosed |
| US-20150266879-A1 | AZAINDOLINES | HOFFMANN-LA ROCHE INC. | 2015-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266879-A1 | AZAINDOLINES | AZI2, H1-5, CCNY | XIAP 1979/4885ELANE 2081/4885BUB1 885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.