Sugi Predict

Sugi Predict / Compounds / SCHEMBL1709787

SCHEMBL1709787

SCHEMBL1709787

CC1(C)Oc2ccc(Nc3nc(N4CCC(CN)(CCO)CC4)c4occc4n3)cc2NC1=O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 17/20 0.54
▸ JAK2 O60674 2/20 0.38
▸ ABL1 P00519 2/20 0.38
▸ INSR P06213 2/20 0.38
▸ LCK P06239 2/20 0.38
▸ FYN P06241 2/20 0.38
▸ RET P07949 2/20 0.38
▸ MST1 P26927 2/20 0.38
▸ MAPK8 P45983 2/20 0.38
▸ TNK2 Q07912 2/20 0.38
▸ MAP4K2 Q12851 2/20 0.38
▸ NTRK2 Q16620 2/20 0.38
▸ AURKA O14965 1/20 0.38
▸ ROCK2 O75116 1/20 0.38
▸ STK16 O75716 1/20 0.38
▸ NTRK1 P04629 1/20 0.38
▸ IGF1R P08069 1/20 0.38
▸ PDGFRB P09619 1/20 0.38
▸ SRC P12931 1/20 0.38
▸ PDGFRA P16234 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3706242 0.94 SYK (0.56) SYKJAK2ABL1INSRLCK
SCHEMBL3709543 0.94 SYK (0.59) SYKJAK2ABL1INSRLCK
SCHEMBL7606089 0.92 SYK (0.56) SYKJAK2ABL1INSRLCK
SCHEMBL3710200 0.89 SYK (0.57) SYKJAK2ABL1INSRLCK
SCHEMBL7602655 0.89 SYK (0.59) SYKJAK2ABL1INSRLCK
SCHEMBL3699807 0.89 SYK (0.59) SYKJAK2ABL1INSRLCK
SCHEMBL7606108 0.89 SYK (0.54) SYKJAK2ABL1INSRLCK
SCHEMBL3700970 0.88 SYK (0.54) SYKJAK2ABL1INSRLCK
SCHEMBL3702190 0.87 SYK (0.56) SYKJAK2ABL1INSRLCK
SCHEMBL3702373 0.87 SYK (0.58) SYKJAK2ABL1INSRLCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8551981-B2 Furo[3,2-d]pyrimidine compounds ABBVIE INC. (US) 2013-10-08 — — US claimed
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-05-17 — — US claimed
US-8551981-B2 Furo[3,2-d]pyrimidine compounds ABBVIE INC. (US) 2013-10-08 — — US disclosed
US-8551981-B2 Furo[3,2-d]pyrimidine compounds ABBVIE INC. (US) 2013-10-08 — — US disclosed
US-8551981-B2 Furo[3,2-d]pyrimidine compounds ABBVIE INC. (US) 2013-10-08 — — US disclosed
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-05-17 — — US disclosed
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-05-17 — — US disclosed
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-05-17 — — US disclosed
WO-2012048222-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-04-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS CDK2, DPYD, CDK3 SYK 1176/4885JAK2 218/4885ABL1 418/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.