Sugi Predict

Sugi Predict / Compounds / SCHEMBL1709894

SCHEMBL1709894

SCHEMBL1709894

Cn1ncc2cc(Nc3nc(N4CCC5(CCNC5)CC4)c4occc4n3)ccc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 7/20 0.41
▸ CCNC P24863 3/20 0.39
▸ CDK8 P49336 3/20 0.39
▸ CDC7 O00311 1/20 0.36
▸ CDK2 P24941 1/20 0.35
▸ MAPKAPK2 P49137 1/20 0.35
▸ TGFBR1 P36897 1/20 0.35
▸ EGFR P00533 1/20 0.34
▸ CYP11B1 P15538 1/20 0.34
▸ BRD4 O60885 1/20 0.34
▸ CREBBP Q92793 1/20 0.34
▸ PIM1 P11309 1/20 0.34
▸ PIM3 Q86V86 1/20 0.34
▸ PIM2 Q9P1W9 1/20 0.34
▸ CDK19 Q9BWU1 2/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ GRM4 Q14833 1/20 0.33
▸ CCNT1 O60563 1/20 0.33
▸ CDK9 P50750 1/20 0.33
▸ DAPK3 O43293 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1709778 0.95 CCNC (0.38) SYKCCNCCDK8CDC7CDK2
SCHEMBL3702853 0.83 BRD4 (0.38) SYKCCNCCDK8CDC7TGFBR1
SCHEMBL3699332 0.81 BRD4 (0.36) SYKCCNCCDK8CDC7TGFBR1
SCHEMBL1290575 0.79 SYK (0.41) SYKCDK8CYP11B1PIM1GRM4
SCHEMBL1709943 0.79 JAK2 (0.45) SYKCYP1A2DAPK3JAK2MAP4K4
SCHEMBL1709898 0.79 SYK (0.46) SYKJAK2STK16ABL1LCK
SCHEMBL3708633 0.79 CDC7 (0.40) SYKCDC7CDK2MAPKAPK2TGFBR1
SCHEMBL3705447 0.79 CDC7 (0.38) SYKCDC7CDK2MAPKAPK2TGFBR1
SCHEMBL3708278 0.78 JAK2 (0.55) SYKCYP11B1DAPK3JAK2MAP4K4
SCHEMBL3709849 0.78 SYK (0.56) SYKJAK2STK16ABL1LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8551981-B2 Furo[3,2-d]pyrimidine compounds ABBVIE INC. (US) 2013-10-08 — — US claimed
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-05-17 — — US claimed
US-8551981-B2 Furo[3,2-d]pyrimidine compounds ABBVIE INC. (US) 2013-10-08 — — US disclosed
US-8551981-B2 Furo[3,2-d]pyrimidine compounds ABBVIE INC. (US) 2013-10-08 — — US disclosed
US-8551981-B2 Furo[3,2-d]pyrimidine compounds ABBVIE INC. (US) 2013-10-08 — — US disclosed
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-05-17 — — US disclosed
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-05-17 — — US disclosed
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-05-17 — — US disclosed
WO-2012048222-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS ABBOTT LABORATORIES (US) 2012-04-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122846-A1 FURO[3,2-d]PYRIMIDINE COMPOUNDS CDK2, DPYD, CDK3 SYK 1176/4885CCNC 346/4885CDK8 38/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.