Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.58 |
| ▸ | JAK2 | O60674 | 3/20 | 0.58 |
| ▸ | ABL1 | P00519 | 3/20 | 0.58 |
| ▸ | LCK | P06239 | 3/20 | 0.58 |
| ▸ | FYN | P06241 | 3/20 | 0.58 |
| ▸ | RET | P07949 | 3/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.58 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.58 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.58 |
| ▸ | PAK4 | O96013 | 2/20 | 0.58 |
| ▸ | LTK | P29376 | 2/20 | 0.58 |
| ▸ | GRK5 | P34947 | 2/20 | 0.58 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.58 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.58 |
| ▸ | TTK | P33981 | 2/20 | 0.58 |
| ▸ | STK16 | O75716 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709923 | 0.87 | SYK (0.61) | SYKJAK2ABL1LCKFYN | |
| SCHEMBL3704057 | 0.85 | SYK (0.55) | SYKJAK2ABL1LCKFYN | |
| SCHEMBL1709820 | 0.82 | SYK (0.52) | SYKJAK2ABL1LCKFYN | |
| SCHEMBL1709847 | 0.82 | SYK (0.58) | SYKJAK2ABL1LCKFYN | |
| SCHEMBL1709757 | 0.82 | SYK (0.56) | SYKJAK2ABL1LCKFYN | |
| SCHEMBL1709925 | 0.81 | SYK (0.58) | SYKJAK2ABL1LCKFYN | |
| SCHEMBL1709924 | 0.81 | MERTK (0.68) | SYKJAK2ABL1LCKFYN | |
| SCHEMBL3711035 | 0.81 | SYK (0.58) | SYKJAK2ABL1LCKFYN | |
| SCHEMBL3708975 | 0.80 | SYK (0.56) | SYKJAK2ABL1LCKFYN | |
| SCHEMBL3700980 | 0.80 | SYK (0.56) | SYKJAK2ABL1LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012048222-A1 | FURO[3,2-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-04-12 | — | — | WO | disclosed |