Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11117779 | 0.77 | PDE3B (0.56) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL11237674 | 0.72 | PDE3B (0.48) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL11238085 | 0.72 | PDE3B (0.48) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL11109882 | 0.72 | PDE3B (0.55) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL11225665 | 0.70 | PDE3B (0.57) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL11238852 | 0.69 | GSK3B (0.50) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL11226843 | 0.68 | NOTUM (0.67) | PDE3BPDE3AGSK3BLMNACDC7 | |
| SCHEMBL11243116 | 0.68 | GSK3B (0.51) | PDE3BPDE3AAURKBINCENPGSK3B | |
| SCHEMBL26620931 | 0.67 | CA12 (0.35) | PDE3BPDE3AKDM4ECYP2C19 | |
| SCHEMBL11224039 | 0.67 | PDE3B (0.47) | PDE3BPDE3AGSK3BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9145393-B2 | Arylpyridinone ITK inhibitors for treating inflammation and cancer | CONFLUENCE LIFE SCIENCES, INC. (US) | 2015-09-29 | — | — | US | disclosed |