Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14923686 | 0.90 | BTK (0.35) | BTKGAAMAOBMAOAEPHX2 | |
| SCHEMBL4690514 | 0.83 | BTK (0.44) | BTKGAAMAOBMAOACTSK | |
| SCHEMBL1468748 | 0.83 | BTK (0.38) | BTKGAAMAOBEPHX2CTSK | |
| SCHEMBL741204 | 0.83 | BTK (0.41) | BTKGAAMAOBMAOACTSK | |
| SCHEMBL14259181 | 0.83 | BTK (0.44) | BTKGAAMAOBMAOACTSK | |
| SCHEMBL25145140 | 0.83 | BTK (0.38) | BTKGAAMAOBEPHX2CTSK | |
| SCHEMBL16095542 | 0.83 | BTK (0.44) | BTKGAAMAOBMAOACTSK | |
| SCHEMBL18940559 | 0.83 | BTK (0.38) | BTKGAAMAOBEPHX2CTSK | |
| SCHEMBL13624954 | 0.83 | BTK (0.38) | BTKGAAMAOBEPHX2CTSK | |
| SCHEMBL5430323 | 0.83 | BTK (0.44) | BTKGAAMAOBMAOACTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344473-A1 | HETEROCYCLIC PIM-KINASE INHIBITORS | Novartis AG (CH) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010026122-A1 | HETEROCYCLIC PIM-KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | disclosed |
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |