Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB3 | P21860 | 3/20 | 0.57 |
| ▸ | BTK | Q06187 | 14/20 | 0.53 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.53 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 6/20 | 0.52 |
| ▸ | LCK | P06239 | 6/20 | 0.51 |
| ▸ | SRC | P12931 | 3/20 | 0.51 |
| ▸ | TEK | Q02763 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 2/20 | 0.50 |
| ▸ | ITK | Q08881 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | YES1 | P07947 | 1/20 | 0.49 |
| ▸ | HCK | P08631 | 1/20 | 0.49 |
| ▸ | FGR | P09769 | 1/20 | 0.49 |
| ▸ | FER | P16591 | 1/20 | 0.49 |
| ▸ | CSK | P41240 | 1/20 | 0.49 |
| ▸ | TEC | P42680 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17106347 | 1.00 | ERBB3 (0.57) | ERBB3BTKNUDT14NUDT5EGFR | |
| SCHEMBL15705844 | 0.92 | ERBB3 (0.54) | ERBB3BTKNUDT14NUDT5EGFR | |
| SCHEMBL15706058 | 0.90 | BTK (0.57) | ERBB3BTKNUDT14NUDT5EGFR | |
| SCHEMBL15705846 | 0.87 | ERBB3 (0.78) | ERBB3BTKNUDT14NUDT5EGFR | |
| SCHEMBL17106291 | 0.87 | ERBB3 (0.78) | ERBB3BTKNUDT14NUDT5EGFR | |
| SCHEMBL22197107 | 0.86 | BTK (0.53) | ERBB3BTKNUDT14NUDT5EGFR | |
| SCHEMBL15706057 | 0.83 | ERBB3 (0.68) | ERBB3BTKNUDT14NUDT5EGFR | |
| SCHEMBL22197159 | 0.83 | BTK (0.58) | ERBB3BTKNUDT14NUDT5EGFR | |
| SCHEMBL15705840 | 0.83 | ERBB3 (0.71) | ERBB3BTKNUDT14NUDT5EGFR | |
| SCHEMBL15648086 | 0.83 | BTK (0.58) | ERBB3BTKNUDT14NUDT5EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE48175-E1 | Hydrophobically tagged small molecules as inducers of protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-08-25 | — | — | US | disclosed |
| US-20180354954-A9 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-12-13 | — | — | US | disclosed |
| US-20180093990-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-04-05 | — | — | US | disclosed |
| US-9758522-B2 | Hydrophobically tagged small molecules as inducers of protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-09-12 | — | — | US | disclosed |
| US-20150274738-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | Dana-Farber Cancer, Institute, Inc. (US) | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180354954-A9 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | MYC, TP53, MDM2 | ERBB3 16/4885BTK 2764/4885NUDT14 2683/4885 |
| US-20150274738-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | MYC, TP53, MDM2 | ERBB3 16/4885BTK 2764/4885NUDT14 2683/4885 |
| US-20180093990-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | MYC, TP53, MDM2 | ERBB3 16/4885BTK 2764/4885NUDT14 2683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.