Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18762405 | 0.89 | NTRK1 (0.78) | NTRK1 | |
| SCHEMBL17110590 | 0.86 | NTRK1 (1.00) | NTRK1 | |
| SCHEMBL17110559 | 0.82 | NTRK1 (0.87) | NTRK1 | |
| SCHEMBL17110592 | 0.82 | NTRK1 (1.00) | NTRK1 | |
| SCHEMBL17110666 | 0.76 | NTRK1 (1.00) | NTRK1 | |
| SCHEMBL17111172 | 0.74 | NTRK1 (1.00) | NTRK1 | |
| SCHEMBL17111162 | 0.74 | NTRK1 (1.00) | NTRK1 | |
| SCHEMBL17111192 | 0.73 | NTRK1 (0.75) | NTRK1 | |
| SCHEMBL17114037 | 0.73 | NTRK1 (0.75) | NTRK1 | |
| SCHEMBL17114034 | 0.73 | NTRK1 (0.74) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122346-A2 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | Merck Sharp & Dohme Corp. (US) | 2017-02-01 | — | — | EP | disclosed |
| WO-2015148344-A2 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | disclosed |
| WO-2015143654-A1 | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | disclosed |