Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | ITK | Q08881 | 2/20 | 0.58 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.52 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16895540 | 1.00 | EGFR (1.00) | EGFRCYP3A4CYP2C9CYP2D6ITK | |
| SCHEMBL17114633 | 1.00 | EGFR (1.00) | EGFRCYP3A4CYP2C9CYP2D6ITK | |
| SCHEMBL16895771 | 1.00 | EGFR (1.00) | EGFRCYP3A4CYP2C9CYP2D6ITK | |
| SCHEMBL16895914 | 1.00 | EGFR (1.00) | EGFRCYP3A4CYP2C9CYP2D6ITK | |
| SCHEMBL16896160 | 0.98 | EGFR (1.00) | EGFRCYP3A4CYP2C9CYP2D6ITK | |
| SCHEMBL16895638 | 0.95 | EGFR (0.91) | EGFRCYP3A4CYP2C9CYP2D6ITK | |
| SCHEMBL16895628 | 0.94 | EGFR (0.94) | EGFRCYP3A4CYP2C9CYP2D6ITK | |
| SCHEMBL16895919 | 0.92 | EGFR (0.85) | EGFRCYP3A4CYP2C9CYP2D6MAP3K7 | |
| SCHEMBL16901767 | 0.92 | EGFR (0.85) | EGFRCYP3A4CYP2C9CYP2D6ITK | |
| SCHEMBL16895746 | 0.91 | EGFR (0.83) | EGFRCYP3A4CYP2C9CYP2D6ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015145388-A2 | METHODS OF TREATING COLORECTAL CANCERS HARBORING UPSTREAM WNT PATHWAY MUTATIONS | NOVARTIS AG (CH) | 2015-10-01 | — | — | WO | disclosed |
| US-8987435-B2 | Oligomeric compounds and methods | ISIS PHARMACEUTICALS, INC. (US) | 2015-03-24 | — | — | US | disclosed |