Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 4/20 | 0.58 |
| ▸ | RAF1 | P04049 | 13/20 | 0.50 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.46 |
| ▸ | LYN | P07948 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | FRK | P42685 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | BLK | P51451 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13603629 | 0.92 | DDR2 (0.68) | DDR2RAF1CSF1RKDRPLK4 | |
| SCHEMBL171054 | 0.84 | DDR2 (0.66) | DDR2RAF1CSF1RKDRPLK4 | |
| SCHEMBL13603631 | 0.83 | DDR2 (0.63) | DDR2RAF1CSF1RKDRPLK4 | |
| SCHEMBL171268 | 0.83 | DDR2 (0.63) | DDR2RAF1CSF1RKDRPLK4 | |
| SCHEMBL171344 | 0.81 | RAF1 (0.58) | DDR2RAF1CSF1RKDRPLK4 | |
| SCHEMBL171237 | 0.81 | DDR2 (0.70) | DDR2RAF1CSF1RKDRPLK4 | |
| SCHEMBL13603451 | 0.80 | DDR2 (0.69) | DDR2RAF1CSF1RKDRPLK4 | |
| SCHEMBL5569460 | 0.80 | RAF1 (0.76) | DDR2RAF1CSF1RKDRPLK4 | |
| SCHEMBL15574602 | 0.79 | RAF1 (0.78) | DDR2RAF1CSF1RKDRPLK4 | |
| SCHEMBL171026 | 0.79 | RAF1 (0.59) | DDR2RAF1CSF1RKDRPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426122-A1 | Methylene urea derivative as RAF kinasse inhibitors | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |