Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.56 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1420352 | 0.83 | PDE10A (0.57) | PDE10ACYSLTR1CYSLTR2GPBAR1HTR2B | |
| SCHEMBL1420106 | 0.82 | PDE10A (0.59) | PDE10ACYSLTR1CYSLTR2GPBAR1HTR2B | |
| SCHEMBL3328917 | 0.81 | PDE10A (0.56) | PDE10ACYSLTR1CYSLTR2GPBAR1HTR2B | |
| SCHEMBL3328309 | 0.81 | PDE10A (0.56) | PDE10ACYSLTR1CYSLTR2GPBAR1HTR2B | |
| SCHEMBL13772898 | 0.80 | CYSLTR1 (0.69) | PDE10ACYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL10547475 | 0.79 | CYSLTR1 (0.76) | PDE10ACYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL12404414 | 0.78 | PDE10A (0.59) | PDE10ACYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL1557640 | 0.78 | PDE10A (0.59) | PDE10ACYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL1420276 | 0.78 | PDE10A (0.56) | PDE10ACYSLTR1CYSLTR2GPBAR1HTR2B | |
| SCHEMBL1420322 | 0.78 | PDE10A (0.56) | PDE10ACYSLTR1CYSLTR2GPBAR1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150274706-A1 | 1,2-DISUBSTITUTED HETEROCYCLIC COMPOUNDS | FMR LLC | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274706-A1 | 1,2-DISUBSTITUTED HETEROCYCLIC COMPOUNDS | PDE12, PDE7A, PDE10A | PDE10A 3/4885CYSLTR1 4215/4885CYSLTR2 4408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.