Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.86 |
| ▸ | MAPT | P10636 | 12/20 | 0.64 |
| ▸ | MEN1 | O00255 | 11/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.60 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29380980 | 0.92 | CFTR (1.00) | CFTRMAPTMEN1KMT2AKDM4E | |
| SCHEMBL12648530 | 0.92 | CFTR (1.00) | CFTRMAPTMEN1KMT2AKDM4E | |
| SCHEMBL29587254 | 0.92 | CFTR (1.00) | CFTRMAPTMEN1KMT2AKDM4E | |
| SCHEMBL12648543 | 0.89 | CFTR (0.94) | CFTRMAPTMEN1KMT2AKDM4E | |
| SCHEMBL12648528 | 0.88 | CFTR (0.77) | CFTRMAPTMEN1KMT2AKDM4E | |
| SCHEMBL14082216 | 0.87 | CFTR (0.83) | CFTRMAPTMEN1KMT2AKDM4E | |
| SCHEMBL12648525 | 0.85 | CFTR (0.78) | CFTRMAPTMEN1KMT2AKDM4E | |
| SCHEMBL12648544 | 0.84 | CFTR (0.72) | CFTRMAPTMEN1KMT2AKDM4E | |
| SCHEMBL14082244 | 0.84 | CFTR (0.78) | CFTRMAPTMEN1KMT2AKDM4E | |
| SCHEMBL12671818 | 0.83 | CFTR (0.70) | CFTRMAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150276719-A2 | A RAPID QUANTITATIVE ASSAY TO MEASURE CFTR FUNCTION IN A PRIMARY INTESTINAL CULTURE MODEL | UMC UTRECHT HOLDING B.V. (NL) | 2015-10-01 | — | — | US | disclosed |