Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.53 |
| ▸ | JAK2 | O60674 | 6/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14320458 | 0.95 | SYK (0.57) | SYKJAK2HTR2AHTR2CMAPT | |
| SCHEMBL14320264 | 0.93 | SYK (0.55) | SYKJAK2HTR2AHTR2CJAK3 | |
| SCHEMBL14320440 | 0.86 | JAK2 (0.55) | SYKJAK2HTR2AHTR2C | |
| SCHEMBL14320283 | 0.82 | SYK (0.58) | SYKJAK2HTR2AHTR2CMAPT | |
| SCHEMBL15651346 | 0.82 | SYK (0.49) | SYKJAK2MAPTSMN1; SMN2ALK | |
| SCHEMBL14320599 | 0.81 | SYK (0.53) | SYKJAK2HTR2AHTR2C | |
| SCHEMBL14320292 | 0.81 | SYK (0.54) | SYKJAK2HTR2AHTR2C | |
| SCHEMBL14320922 | 0.81 | SYK (0.51) | SYKJAK2ALK | |
| SCHEMBL15652909 | 0.81 | SYK (0.61) | SYKJAK2ALK | |
| SCHEMBL15652312 | 0.81 | SYK (0.49) | SYKJAK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699579-B1 | PYRAZOLO[4,3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2015-10-07 | — | — | EP | claimed |