Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.81 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15700580 | 0.92 | EZH2 (0.82) | EZH2HDAC1HDAC6 | |
| SCHEMBL30395844 | 0.92 | EZH2 (0.78) | EZH2HDAC1HDAC6 | |
| SCHEMBL17148725 | 0.92 | EZH2 (0.78) | EZH2HDAC1HDAC6 | |
| SCHEMBL15700581 | 0.90 | EZH2 (0.91) | EZH2HDAC1HDAC6 | |
| SCHEMBL17136199 | 0.90 | EZH2 (0.73) | EZH2 | |
| SCHEMBL13276844 | 0.90 | EZH2 (1.00) | EZH2HDAC1HDAC6 | |
| SCHEMBL18715254 | 0.90 | EZH2 (1.00) | EZH2HDAC1HDAC6 | |
| SCHEMBL13276843 | 0.90 | EZH2 (1.00) | EZH2HDAC1HDAC6 | |
| SCHEMBL13277247 | 0.89 | EZH2 (1.00) | EZH2HDAC1HDAC6 | |
| SCHEMBL18715183 | 0.89 | EZH2 (0.89) | EZH2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240165121-A1 | SUBSTITUTED BENZENE COMPOUNDS | EPIZYME INC (US) | 2024-05-23 | — | — | US | disclosed |
| US-11642348-B2 | Substituted benzene compounds | Epizyme, Inc. (US) | 2023-05-09 | — | — | US | disclosed |
| US-20210060027-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. | 2021-03-04 | — | — | US | disclosed |
| EP-3725314-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-2906537-B1 | SUBSTITUTED BENZENE COMPOUNDS | EPIZYME INC (US) | 2020-03-11 | — | — | EP | disclosed |
| US-10092572-B2 | Substituted benzene compounds | Epizyme, Inc. (US) | 2018-10-09 | — | — | US | disclosed |
| US-20150284370-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. | 2015-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284370-A1 | SUBSTITUTED BENZENE COMPOUNDS | CYP1B1, TP53, VHL | EZH2 2519/4885HDAC1 2940/4885HDAC6 2884/4885 |
| US-10092572-B2 | Substituted benzene compounds | CYP1B1, TP53, VHL | EZH2 2519/4885HDAC1 2940/4885HDAC6 2884/4885 |
| US-20210060027-A1 | SUBSTITUTED BENZENE COMPOUNDS | CYP1B1, TP53, VHL | EZH2 2519/4885HDAC1 2940/4885HDAC6 2884/4885 |
| US-20240165121-A1 | SUBSTITUTED BENZENE COMPOUNDS | CYP1B1, TP53, VHL | EZH2 2519/4885HDAC1 2940/4885HDAC6 2884/4885 |
| US-11642348-B2 | Substituted benzene compounds | CYP1B1, TP53, VHL | EZH2 2519/4885HDAC1 2940/4885HDAC6 2884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.