Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 4/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | RAF1 | P04049 | 8/20 | 0.49 |
| ▸ | KDR | P35968 | 7/20 | 0.49 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.48 |
| ▸ | BRAF | P15056 | 4/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15573069 | 0.92 | DDR2 (0.65) | DDR2MAPK14RAF1KDRP2RX3 | |
| SCHEMBL13603632 | 0.89 | DDR2 (0.72) | DDR2MAPK14RAF1KDRP2RX3 | |
| SCHEMBL15574740 | 0.89 | DDR2 (0.71) | DDR2MAPK14RAF1KDRP2RX3 | |
| SCHEMBL15574169 | 0.87 | DDR2 (0.82) | DDR2MAPK14RAF1KDRP2RX3 | |
| SCHEMBL15575325 | 0.86 | DDR2 (0.59) | DDR2MAPK14RAF1KDRP2RX3 | |
| SCHEMBL13603493 | 0.85 | DDR2 (0.61) | DDR2MAPK14RAF1KDRP2RX3 | |
| SCHEMBL15574727 | 0.85 | MAPK14 (0.58) | DDR2MAPK14RAF1KDRP2RX3 | |
| SCHEMBL13603483 | 0.84 | DDR2 (0.56) | DDR2MAPK14RAF1KDRP2RX3 | |
| SCHEMBL15574158 | 0.84 | DDR2 (0.58) | DDR2MAPK14RAF1KDREPHX2 | |
| SCHEMBL13603494 | 0.83 | DDR2 (0.61) | DDR2MAPK14RAF1KDREPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426122-A1 | Methylene urea derivative as RAF kinasse inhibitors | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |