⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17138397 | 0.77 | — | — | |
| SCHEMBL20241157 | 0.74 | — | — | |
| SCHEMBL17138430 | 0.71 | — | — | |
| SCHEMBL17138398 | 0.71 | — | — | |
| SCHEMBL3396143 | 0.68 | — | — | |
| SCHEMBL20243466 | 0.67 | GRIN2D (0.40) | — | |
| SCHEMBL3396359 | 0.65 | — | — | |
| SCHEMBL15991986 | 0.64 | HPGD (0.36) | — | |
| SCHEMBL10945091 | 0.64 | — | — | |
| SCHEMBL7618847 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115703770-A | Pyrimidinamine compound and composition and application thereof | 深圳范恩柯尔精准医疗有限公司 | 2023-02-17 | — | — | CN | disclosed |
| EP-3551630-A1 | IMIDAZO [1,5-A]PYRAZINE DERIVATIVES AS PI3Kdelta INHIBITORS | Beigene, Ltd. (KY) | 2019-10-16 | — | — | EP | disclosed |
| WO-2018103688-A1 | IMIDAZO [1,5-A] PYRAZINE DERIVATIVES AS PI3Kdelta INHIBITORS | BEIGENE, LTD. (KY) | 2018-06-14 | — | — | WO | disclosed |
| US-9527848-B2 | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2016-12-27 | — | — | US | disclosed |
| US-20150284390-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2015-10-08 | — | — | US | disclosed |