Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.43 |
| ▸ | JAK1 | P23458 | 15/20 | 0.43 |
| ▸ | JAK3 | P52333 | 15/20 | 0.43 |
| ▸ | TYK2 | P29597 | 8/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.37 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1713888 | 0.85 | CDC7 (0.48) | — | |
| SCHEMBL1713886 | 0.85 | CDC7 (0.48) | — | |
| SCHEMBL12460392 | 0.80 | KMT2A (0.46) | — | |
| SCHEMBL1714015 | 0.76 | CDC7 (0.42) | — | |
| SCHEMBL1714013 | 0.76 | CDC7 (0.42) | — | |
| SCHEMBL1714067 | 0.73 | HRH4 (0.36) | — | |
| SCHEMBL13676713 | 0.69 | JAK2 (0.34) | JAK2 | |
| SCHEMBL2279760 | 0.67 | JAK3 (0.55) | JAK2JAK1JAK3TYK2PIK3C3 | |
| SCHEMBL1713964 | 0.66 | MAP3K12 (0.34) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL1713965 | 0.66 | MAP3K12 (0.34) | JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094699-B1 | NEW IMIDAZOLONE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS PROTEIN KINASE INHIBITORS, IN PARTICULAR CDC7 | SANOFI AVENTIS (FR) | 2011-07-20 | — | — | EP | disclosed |