Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.47 |
| ▸ | PIM1 | P11309 | 4/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28110891 | 0.98 | PARP1 (0.46) | PARP1PIM1RPS6KA3ABL1AURKA | |
| SCHEMBL24392463 | 0.83 | PARP1 (0.49) | PARP1PIM1RPS6KA3ABL1AURKA | |
| SCHEMBL17142276 | 0.81 | PARP1 (0.51) | PARP1PIM1RPS6KA3ABL1AURKA | |
| SCHEMBL17142252 | 0.81 | PARP1 (0.51) | PARP1PIM1RPS6KA3ABL1AURKA | |
| Hydrochloric Acid SCHEMBL28110843 | 0.80 | PARP1 (0.50) | PARP1PIM1RPS6KA3ABL1AURKA | |
| Hydrochloric Acid SCHEMBL28110896 | 0.80 | PARP1 (0.50) | PARP1PIM1RPS6KA3ABL1AURKA | |
| SCHEMBL3234194 | 0.78 | PARP1 (0.63) | PARP1PIM1RPS6KA3ABL1AURKA | |
| SCHEMBL31728550 | 0.77 | IP6K1 (0.51) | PARP1PIM1RPS6KA3ABL1AURKA | |
| SCHEMBL3034158 | 0.77 | BRD4 (0.47) | ABL1PRKD3RETPRKCQDYRK1A | |
| SCHEMBL15845792 | 0.75 | PARP1 (0.47) | PARP1PIM1RPS6KA3ABL1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3126354-B1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H LUNDBECK AS (DK) | 2020-01-22 | — | — | EP | disclosed |
| US-20190144434-A1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2019-05-16 | — | — | US | disclosed |
| US-10005764-B2 | Halogenated quinazolin-THF-amines as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2018-06-26 | — | — | US | disclosed |
| EP-3126354-A1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. Lundbeck A/S (DK) | 2017-02-08 | — | — | EP | disclosed |
| US-20170022186-A1 | Halogenated Quinazolin-THF-Amines as PDE1 Inhibitors | H. LUNDBECK A/S (DK) | 2017-01-26 | — | — | US | disclosed |
| WO-2015150254-A1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2015-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144434-A1 | HALOGENATED QUINAZOLIN-THF-AMINES AS PDE1 INHIBITORS | PDE12, PDE3A, PDE7B | PARP1 153/4885PIM1 3565/4885RPS6KA3 2903/4885 |
| US-10005764-B2 | Halogenated quinazolin-THF-amines as PDE1 inhibitors | PDE12, PDE3A, PDE7B | PARP1 153/4885PIM1 3565/4885RPS6KA3 2903/4885 |
| US-20170022186-A1 | Halogenated Quinazolin-THF-Amines as PDE1 Inhibitors | PDE12, PDE3A, PDE7B | PARP1 153/4885PIM1 3565/4885RPS6KA3 2903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.