Sugi Predict

Sugi Predict / Compounds / SCHEMBL17144239

SCHEMBL17144239

SCHEMBL17144239

COc1cccc2c1C(=O)N(c1ccc(Cl)c(C(F)(F)F)c1)C2

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 6/20 0.53
▸ RAB9A P51151 6/20 0.53
▸ TP53 P04637 2/20 0.53
▸ TSHR P16473 2/20 0.53
▸ SMN1; SMN2 Q16637 2/20 0.53
▸ MAPT P10636 1/20 0.53
▸ NFKB1 P19838 1/20 0.53
▸ NFKB2 Q00653 1/20 0.53
▸ RELA Q04206 1/20 0.53
▸ HTR2C P28335 9/20 0.51
▸ HTR2B P41595 7/20 0.51
▸ HTR2A P28223 6/20 0.51
▸ GAA P10253 1/20 0.47
▸ POLB P06746 3/20 0.42
▸ KDM4E B2RXH2 1/20 0.42
▸ ESR1 P03372 1/20 0.42
▸ NR4A1 P22736 1/20 0.42
▸ APEX1 P27695 1/20 0.42
▸ PTPN7 P35236 1/20 0.42
▸ RECQL P46063 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31707501 1.00 NPC1 (0.53) NPC1RAB9ATP53TSHRSMN1; SMN2
SCHEMBL24080158 0.91 NPC1 (0.48) NPC1RAB9ATP53TSHRSMN1; SMN2
SCHEMBL19805573 0.88 HTR2C (0.47) NPC1RAB9ATP53TSHRSMN1; SMN2
SCHEMBL19052092 0.88 NPC1 (0.54) NPC1RAB9ATP53TSHRSMN1; SMN2
SCHEMBL18804931 0.85 PARP1 (0.45) NPC1RAB9ATP53TSHRSMN1; SMN2
SCHEMBL19805572 0.84 HTR2C (0.47) NPC1RAB9ATP53TSHRSMN1; SMN2
SCHEMBL17154499 0.83 NPC1 (0.41) NPC1RAB9ATP53TSHRSMN1; SMN2
SCHEMBL22340589 0.78 NPC1 (0.47) NPC1RAB9ATP53TSHRSMN1; SMN2
SCHEMBL10067181 0.77 NPC1 (0.54) NPC1RAB9ATP53SMN1; SMN2MAPT
SCHEMBL18814827 0.77 AR (0.49) RAB9AMAPTPOLBKDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12239618-B2 Histone acetyltransferase activators and compositions and uses thereof THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2025-03-04 — — US disclosed
US-20230165813-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2023-06-01 — — US disclosed
US-20230165813-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2023-06-01 — — US disclosed
US-20230165813-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2023-06-01 — — US disclosed
US-11406608-B2 Histone acetyltransferase activators and compositions and uses thereof THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2022-08-09 — — US disclosed
US-11191768-B2 Histone acetyltransferase activators and uses thereof THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2021-12-07 — — US disclosed
US-20200330410-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2020-10-22 — — US disclosed
US-20200330410-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2020-10-22 — — US disclosed
US-10653648-B2 Histone acetyltransferase activators and compositions and uses thereof THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2020-05-19 — — US disclosed
US-10653648-B2 Histone acetyltransferase activators and compositions and uses thereof THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2020-05-19 — — US disclosed
WO-2018017858-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2018-01-25 — — WO disclosed
US-20180021273-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2018-01-25 — — US disclosed
US-20180021273-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2018-01-25 — — US disclosed
US-20180021273-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2018-01-25 — — US disclosed
US-20170182054-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2017-06-29 — — US disclosed
US-20170182054-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2017-06-29 — — US disclosed
US-20170182054-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2017-06-29 — — US disclosed
EP-3126332-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF The Trustees of Columbia University in the City of New York (US) 2017-02-08 — — EP disclosed
WO-2015153410-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2015-10-08 — — WO disclosed
WO-2015153410-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2015-10-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11406608-B2 Histone acetyltransferase activators and compositions and uses thereof HDAC6, HDAC9, HDAC5 NPC1 1858/4885RAB9A 1838/4885TP53 382/4885
US-20170182054-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF EP300, KAT2A, HTT NPC1 1072/4885RAB9A 1494/4885TP53 455/4885
US-20180021273-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF HDAC6, HDAC9, HDAC5 NPC1 1858/4885RAB9A 1838/4885TP53 382/4885
US-12239618-B2 Histone acetyltransferase activators and compositions and uses thereof HDAC6, HDAC9, HDAC5 NPC1 1858/4885RAB9A 1838/4885TP53 382/4885
US-11191768-B2 Histone acetyltransferase activators and uses thereof EP300, KAT2A, HTT NPC1 1072/4885RAB9A 1494/4885TP53 455/4885
US-20200330410-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF HDAC6, HDAC9, HDAC5 NPC1 1858/4885RAB9A 1838/4885TP53 382/4885
US-10653648-B2 Histone acetyltransferase activators and compositions and uses thereof HDAC6, HDAC9, HDAC5 NPC1 1858/4885RAB9A 1838/4885TP53 382/4885
US-20230165813-A1 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF HDAC6, HDAC9, HDAC5 NPC1 1858/4885RAB9A 1838/4885TP53 382/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.