Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.38 |
| ▸ | KDM5C | P41229 | 3/20 | 0.38 |
| ▸ | KDM4A | O75164 | 2/20 | 0.38 |
| ▸ | KDM6B | O15054 | 2/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4B | O94953 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19741716 | 1.00 | SIRT2 (0.40) | SIRT2SMN1; SMN2KDM5BKDM5CKDM4A | |
| SCHEMBL15994210 | 0.75 | KDM5B (0.56) | SIRT2KDM5BKDM5CKDM4AKDM6B | |
| SCHEMBL508770 | 0.74 | ACACB (0.46) | SMN1; SMN2KDM5BKDM5CKDM4AKDM6B | |
| SCHEMBL30097021 | 0.74 | ACACB (0.46) | SMN1; SMN2KDM5BKDM5CKDM4AKDM6B | |
| SCHEMBL16291634 | 0.72 | KDM5B (0.52) | SIRT2KDM5BKDM5CKDM4AKDM6B | |
| SCHEMBL18286833 | 0.71 | SYK (0.38) | KDM5BKDM5CKDM4AKDM6BKDM5A | |
| SCHEMBL17763274 | 0.71 | KDM5B (0.57) | SIRT2KDM5BKDM5CKDM4AKDM6B | |
| SCHEMBL27425092 | 0.70 | KDM5B (0.42) | SIRT2KDM5BKDM5CKDM4AKDM6B | |
| SCHEMBL19741656 | 0.70 | MEN1 (0.40) | KDM4EALDH1A1MAPTKMT2ANPSR1 | |
| SCHEMBL17144142 | 0.70 | MEN1 (0.40) | KDM4EALDH1A1MAPTKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170369444-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EPITHERAPEUTICS APS (DK) | 2017-12-28 | — | — | US | claimed |
| EP-3126345-A1 | INHIBITORS OF HISTONE DEMETHYLASES | Gilead Sciences, Inc. (US) | 2017-02-08 | — | — | EP | claimed |
| WO-2015153498-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EPITHERAPEUTICS, APS (DK) | 2015-10-08 | — | — | WO | claimed |
| US-20170369444-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EPITHERAPEUTICS APS (DK) | 2017-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170369444-A1 | INHIBITORS OF HISTONE DEMETHYLASES | KDM1B, KDM3A, KDM1A | SIRT2 708/4885SMN1; SMN2 2826/4885KDM5B 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.