Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17154505 | 0.92 | MAPT (0.42) | KMT2AGRM5KCNN4MAPTKDM4E | |
| SCHEMBL17154504 | 0.91 | KCNN4 (0.41) | KMT2AGRM5KCNN4MAPTKDM4E | |
| SCHEMBL17154511 | 0.90 | KCNN4 (0.41) | KMT2AGRM5KCNN4MAPTKDM4E | |
| SCHEMBL20585333 | 0.89 | KDM4E (0.47) | KMT2AKCNN4MAPTKDM4EMAPK1 | |
| SCHEMBL17154489 | 0.88 | GALR3 (0.42) | KMT2AGRM5KCNN4MAPTKDM4E | |
| SCHEMBL17154487 | 0.87 | UTS2R (0.41) | KMT2AGRM5KCNN4MAPTKDM4E | |
| SCHEMBL17154486 | 0.87 | KCNN4 (0.40) | KMT2AGRM5KCNN4MAPTKDM4E | |
| SCHEMBL19052100 | 0.86 | MAPT (0.53) | KMT2AGRM5MAPTKDM4EMAPK1 | |
| SCHEMBL17154506 | 0.84 | KDM4E (0.39) | KMT2AKCNN4MAPTKDM4EMAPK1 | |
| SCHEMBL17145059 | 0.81 | MAPT (0.47) | KMT2AKCNN4MAPTKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3487836-B1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | UNIV COLUMBIA (US) | 2025-10-22 | — | — | EP | disclosed |
| US-20230165813-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2023-06-01 | — | — | US | disclosed |
| US-20230165813-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2023-06-01 | — | — | US | disclosed |
| US-11406608-B2 | Histone acetyltransferase activators and compositions and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2022-08-09 | — | — | US | disclosed |
| US-11191768-B2 | Histone acetyltransferase activators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-12-07 | — | — | US | disclosed |
| US-11191768-B2 | Histone acetyltransferase activators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-12-07 | — | — | US | disclosed |
| US-20200330410-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2020-10-22 | — | — | US | disclosed |
| US-20200330410-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2020-10-22 | — | — | US | disclosed |
| US-10653648-B2 | Histone acetyltransferase activators and compositions and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-05-19 | — | — | US | disclosed |
| US-10653648-B2 | Histone acetyltransferase activators and compositions and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-05-19 | — | — | US | disclosed |
| US-20180021273-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-01-25 | — | — | US | disclosed |
| US-20180021273-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-01-25 | — | — | US | disclosed |
| US-20180021273-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2018-01-25 | — | — | US | disclosed |
| WO-2018017858-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-01-25 | — | — | WO | disclosed |
| US-20170182054-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2017-06-29 | — | — | US | disclosed |
| US-20170182054-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2017-06-29 | — | — | US | disclosed |
| US-20170182054-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2017-06-29 | — | — | US | disclosed |
| EP-3126332-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2017-02-08 | — | — | EP | disclosed |
| WO-2015153410-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-10-08 | — | — | WO | disclosed |
| WO-2015153410-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11406608-B2 | Histone acetyltransferase activators and compositions and uses thereof | HDAC6, HDAC9, HDAC5 | KMT2A 49/4885GRM5 2727/4885KCNN4 4681/4885 |
| US-20170182054-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF | EP300, KAT2A, HTT | KMT2A 59/4885GRM5 3077/4885KCNN4 4802/4885 |
| US-20180021273-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | HDAC6, HDAC9, HDAC5 | KMT2A 49/4885GRM5 2727/4885KCNN4 4681/4885 |
| US-11191768-B2 | Histone acetyltransferase activators and uses thereof | EP300, KAT2A, HTT | KMT2A 59/4885GRM5 3077/4885KCNN4 4802/4885 |
| US-20200330410-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | HDAC6, HDAC9, HDAC5 | KMT2A 49/4885GRM5 2727/4885KCNN4 4681/4885 |
| US-10653648-B2 | Histone acetyltransferase activators and compositions and uses thereof | HDAC6, HDAC9, HDAC5 | KMT2A 49/4885GRM5 2727/4885KCNN4 4681/4885 |
| US-20230165813-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF | HDAC6, HDAC9, HDAC5 | KMT2A 49/4885GRM5 2727/4885KCNN4 4681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.