Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | SLC9A3 | P48764 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17145178 | 0.93 | SMN1; SMN2 (0.38) | SMN1; SMN2HPGDHTTHSD17B10POLB | |
| SCHEMBL18264887 | 0.92 | SMN1; SMN2 (0.37) | SMN1; SMN2HPGDHTTHSD17B10POLB | |
| SCHEMBL277686 | 0.92 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDHTTHSD17B10POLB | |
| SCHEMBL24686922 | 0.90 | SMN1; SMN2 (0.47) | SMN1; SMN2HPGDHTTHSD17B10POLB | |
| SCHEMBL13056345 | 0.90 | SMN1; SMN2 (0.37) | SMN1; SMN2HPGDHTTHSD17B10POLB | |
| SCHEMBL13056342 | 0.89 | SMN1; SMN2 (0.37) | SMN1; SMN2HPGDHTTHSD17B10POLB | |
| SCHEMBL17357524 | 0.89 | SMN1; SMN2 (0.37) | SMN1; SMN2HPGDHTTHSD17B10POLB | |
| SCHEMBL14728245 | 0.88 | HPGD (0.36) | SMN1; SMN2HPGDHTTHSD17B10POLB | |
| SCHEMBL14728243 | 0.88 | HPGD (0.36) | SMN1; SMN2HPGDHTTHSD17B10POLB | |
| SCHEMBL13776353 | 0.88 | SMN1; SMN2 (0.36) | SMN1; SMN2HPGDHTTHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150649-B2 | Potent conjugates and hydrophilic linkers | IMMUNOGEN, INC. (US) | 2015-10-06 | — | — | US | disclosed |