Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 20/20 | 0.67 |
| ▸ | UBA3 | Q8TBC4 | 20/20 | 0.67 |
| ▸ | SAE1 | Q9UBE0 | 6/20 | 0.46 |
| ▸ | UBA2 | Q9UBT2 | 6/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL782962 | 0.85 | NAE1 (0.67) | NAE1UBA3SAE1UBA2 | |
| SCHEMBL782768 | 0.80 | NAE1 (1.00) | NAE1UBA3SAE1UBA2 | |
| SCHEMBL782948 | 0.76 | NAE1 (0.77) | NAE1UBA3SAE1UBA2 | |
| SCHEMBL782426 | 0.76 | NAE1 (0.77) | NAE1UBA3SAE1UBA2 | |
| SCHEMBL2879315 | 0.76 | NAE1 (0.77) | NAE1UBA3SAE1UBA2 | |
| SCHEMBL19184629 | 0.75 | NAE1 (0.79) | NAE1UBA3SAE1UBA2 | |
| SCHEMBL782894 | 0.74 | NAE1 (0.60) | NAE1UBA3 | |
| SCHEMBL783690 | 0.74 | NAE1 (0.59) | NAE1UBA3 | |
| SCHEMBL12392783 | 0.74 | NAE1 (0.59) | NAE1UBA3 | |
| SCHEMBL783623 | 0.74 | NAE1 (0.59) | NAE1UBA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150525-B2 | Heteroaryl compounds useful as inhibitors of E1 activating enzymes | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-10-06 | — | — | US | disclosed |