SCHEMBL171455

SCHEMBL171455

c1nc(-c2cn[nH]c2)c2cc[nH]c2n1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 9/20 0.61
AURKA O14965 3/20 0.59
AURKB Q96GD4 2/20 0.59
INCENP Q9NQS7 1/20 0.59
TPX2 Q9ULW0 1/20 0.59
BRD4 O60885 1/20 0.54
IKBKB O14920 1/20 0.52
CHUK O15111 1/20 0.52
JAK3 P52333 6/20 0.50
DAPK3 O43293 3/20 0.50
PRKD3 O94806 3/20 0.50
MAP4K4 O95819 3/20 0.50
PAK4 O96013 3/20 0.50
CSF1R P07333 3/20 0.50
RET P07949 3/20 0.50
MET P08581 3/20 0.50
PIM1 P11309 3/20 0.50
FGFR1 P11362 3/20 0.50
PRKACA P17612 3/20 0.50
FLT1 P17948 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29541277 1.00 JAK2 (0.61) JAK2AURKAAURKBINCENPTPX2
SCHEMBL4006751 0.76 JAK2 (1.00) JAK2AURKAAURKBBRD4IKBKB
SCHEMBL4115515 0.75 JAK2 (0.54) JAK2AURKAAURKBBRD4IKBKB
SCHEMBL4116922 0.75 JAK2 (0.57) JAK2AURKAAURKBBRD4IKBKB
SCHEMBL13695900 0.75 BRD4 (0.54) JAK2AURKAAURKBBRD4IKBKB
SCHEMBL13765436 0.75 JAK2 (0.72) JAK2AURKAAURKBBRD4IKBKB
SCHEMBL2239177 0.74 AURKB (1.00) JAK2AURKAAURKBINCENPTPX2
SCHEMBL31061291 0.74 AURKB (1.00) JAK2AURKAAURKBINCENPTPX2
SCHEMBL25837844 0.74 AURKA (0.55) JAK2AURKAAURKBINCENPTPX2
SCHEMBL4582353 0.73 JAK2 (0.70) JAK2AURKAAURKBBRD4IKBKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4658274-A1 CRYSTALLINE FORM OF DEURUXOLITINIB SUN PHARMACEUTICAL INDUSTRIES, INC. (US) 2025-12-10 EP disclosed
US-20250340559-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE HOLDINGS CORP (US) 2025-11-06 US disclosed
US-20250326762-A1 CRYSTALLINE FORM OF DEURUXOLITINIB SUN PHARMACEUTICAL IND INC (US) 2025-10-23 US disclosed
US-12247030-B2 Process for preparing compositions comprising an enantiomeric excess of a substituted pyrrolo[2,3-d]pyrimidine INCYTE HOLDINGS CORPORATION (US) 2025-03-11 US disclosed
US-12247034-B1 Crystalline form of deuruxolitinib phosphate SUN PHARMACEUTICAL INDUSTRIES, INC. (US) 2025-03-11 US disclosed
EP-4501410-A2 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS Incyte Holdings Corporation (US) 2025-02-05 EP disclosed
CN-119306753-A Methods for preparing JAK inhibitors and related intermediate compounds 因西特控股公司 2025-01-14 CN disclosed
EP-3272738-B1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE HOLDINGS CORP (US) 2024-11-13 EP disclosed
CN-108395433-B Methods for preparing JAK inhibitors and related intermediate compounds 因西特控股公司 2024-10-22 CN disclosed
EP-3452039-B1 TREATMENT OF HAIR LOSS DISORDERS WITH DEUTERATED JAK INHIBITORS SUN PHARMACEUTICAL IND INC (US) 2024-07-03 EP disclosed
EP-2343299-A1 Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors Incyte Corporation (US) 2011-07-13 EP disclosed
US-20110086810-A1 HYDROXYL, KETO, AND GLUCURONIDE DERIVATIVES OF 3-(4-(7H-PYRROLO[2,3-d] PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE INCYTE CORPORATION (US) 2011-04-14 US disclosed
US-20110086810-A1 HYDROXYL, KETO, AND GLUCURONIDE DERIVATIVES OF 3-(4-(7H-PYRROLO[2,3-d] PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE INCYTE CORPORATION (US) 2011-04-14 US disclosed
US-20100190981-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION 2010-07-29 US disclosed
WO-2010083283-A2 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION (US) 2010-07-22 WO disclosed
US-20090227607-A1 DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES VERTEX PHARMACEUTICALS INCORPORATED 2009-09-10 US disclosed
US-20090227607-A1 DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES VERTEX PHARMACEUTICALS INCORPORATED 2009-09-10 US disclosed
US-20090088445-A1 Deazapurines useful as inhibitors of Janus kinases VERTEX PHARMACEUTICALS INCORPORATED 2009-04-02 US disclosed
US-20090088445-A1 Deazapurines useful as inhibitors of Janus kinases VERTEX PHARMACEUTICALS INCORPORATED 2009-04-02 US disclosed
WO-2007070514-A1 HETEROARYL SUBSTITUTED PYRROLO[2,3-B]PYRIDINES AND PYRROLO[2,3-B]PYRIMIDINES AS JANUS KINASE INHIBITORS INCYTE CORPORATION (US) 2007-06-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12247030-B2 Process for preparing compositions comprising an enantiomeric excess of a substituted pyrrolo[2,3-d]pyrimidine DPYD, TYMS, TYMP JAK2 2515/4885AURKA 727/4885AURKB 1133/4885
US-20250326762-A1 CRYSTALLINE FORM OF DEURUXOLITINIB JAK1, CDK4, JAK3 JAK2 12/4885AURKA 1377/4885AURKB 1560/4885
US-20090088445-A1 Deazapurines useful as inhibitors of Janus kinases JAK1, JAK3, JAK2 JAK2 3/4885AURKA 289/4885AURKB 455/4885
US-20110086810-A1 HYDROXYL, KETO, AND GLUCURONIDE DERIVATIVES OF 3-(4-(7H-PYRROLO[2,3-d] PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE UGT1A4, UGT1A3, UGT1A1 JAK2 3506/4885AURKA 1265/4885AURKB 1378/4885
US-20100190981-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS JAK3, JAK1, JAK2 JAK2 3/4885AURKA 345/4885AURKB 498/4885
US-20250340559-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS JAK3, JAK1, JAK2 JAK2 3/4885AURKA 345/4885AURKB 498/4885
US-12247034-B1 Crystalline form of deuruxolitinib phosphate JAK1, PRKDC, PTPN4 JAK2 15/4885AURKA 1384/4885AURKB 1661/4885
US-20090227607-A1 DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES JAK1, JAK3, JAK2 JAK2 3/4885AURKA 289/4885AURKB 455/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.